Research
My research focuses on genetics, genomics, and their clinical applications, with particular emphasis on rare genetic disorders, cancer biology, and the psychosocial impacts of genomic medicine. Below are preprints and publications from my work.
Investigating Cisplatin Resistance in Cervical Cancer Cell Lines
This research investigates the molecular mechanisms underlying cisplatin resistance in cervical cancer. Using cisplatin-resistant and cisplatin-sensitive cell lines, we identified key genes and pathways associated with chemoresistance. The study involved long-term cell culture maintenance, gene expression analysis, and functional assays to understand the genetic basis of treatment resistance in cervical cancer.
Research Experience
Project Researcher, Cancer Institute (WIA) – Department of Molecular Oncology
March 2024 – March 2025
As a Project Researcher, I led investigations into cisplatin resistance mechanisms in cervical cancer. My work involved designing and executing experiments comparing cisplatin-resistant and cisplatin-sensitive cervical cancer cell lines to identify genes associated with chemoresistance. I maintained long-term cell cultures, performed RNA expression analysis, and conducted functional assays to validate findings. Additionally, I mentored undergraduate interns, providing training in laboratory techniques and experimental design. This research contributes to understanding the genetic basis of treatment resistance, which is critical for developing more effective therapeutic strategies for cervical cancer patients.
Research Assistant (Master's Thesis), University of Glasgow
April 2023 – August 2023
For my Master's thesis, I conducted a comprehensive systematic review assessing the psychosocial impact of newborn genomic screening on parents and caregivers. This research involved rigorous literature review, data extraction, and synthesis of qualitative and quantitative findings. The work explored how integrating genomic screening into routine newborn care affects parental decision-making, emotional well-being, and family dynamics. This research highlighted the importance of genetic counselling and support services in genomic medicine, contributing to evidence-based practice in genetic counselling services.
Research Assistant, Bharath Institute of Higher Education and Research
June 2019 – June 2022
During my undergraduate studies, I spearheaded multiple genotyping projects analyzing genetic variation across more than 100 samples. I performed PCR assays, STR analysis, and genotyping to identify genetic markers and variations. Additionally, I contributed to COVID-19 diagnostic efforts, performing over 75 PCR assays during the pandemic. This experience provided me with strong foundational skills in molecular biology techniques, data analysis, and laboratory management. I also received the University Research Award (2022) for outstanding undergraduate research on migraine triggers, which involved a global comparative study analyzing migraine triggers and their impacts across different populations.
Research Focus Areas
- Cancer Biology: Investigating genetic mechanisms of chemoresistance, particularly in cervical cancer, with focus on identifying biomarkers and therapeutic targets.
- Genomic Medicine: Exploring the psychosocial and clinical impacts of genomic screening, genetic counselling, and personalized medicine approaches.
- Rare Genetic Disorders: Research interest in understanding the genetic basis of rare conditions and improving diagnostic and therapeutic strategies.
- Genetic Variation Analysis: Genotyping projects and population genetics studies to identify genetic markers and variations associated with disease.
Technical Skills & Methodologies
- Molecular Biology: PCR, genotyping, STR analysis, RNA expression analysis, cell culture, and live cell imaging
- Data Analysis: Statistical methods, systematic reviews, meta-analysis, and bioinformatics pipelines
- Research Design: Experimental design, literature review, data extraction, and synthesis methodologies
- Laboratory Management: Long-term cell culture maintenance, quality control, and protocol optimization
For a complete list of publications and detailed research background, please see my resume or contact me directly.